Sorry men, scientists say ibuprofen may be bad for your testicles

Bryan Strickland
January 10, 2018

"For men, it is important their testosterone level remains at a stable level".

It has already been linked with fertility problems in women taking the drug.

Previous research by European scientists showed that male babies whose mothers took ibuprofen experienced disturbances to their endocrine system, according to CNN.

Researchers looked at 31 male participants and found that taking ibuprofen reduced production of testosterone by almost a quarter in the space of around six weeks. The men were then divided into two groups, 14 in an ibuprofen group and 17 in a placebo group.

Researchers tested testicles from prostate cancer donors and cultured testes cells, which revealed that ibuprofen can affect hormones, suppressing production of testosterone through transcriptional repression, leading to compensated hypogonadism.

At the end of the study, the men who took ibuprofen had developed compensated hypogonadism, a condition usually associated with smokers, elderly men and those with reproductive issues or physical disorders. But researchers are concerned about long-term use among athletes. Over-the-counter pain-relieving analgesics like Motrin and Advil are some of the most commonly used pharmaceutical compounds in the world used to treat aches, pains, fever, and arthritis.

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The study shows that it has a negative impact on the testicles of young men, altering their sex hormone production and affecting their reproductive health.

According to the Proceedings of the National Academy of Sciences, prolonged and heavy use of the drug "alters human testicular physiology to produce a state of compensated hypogonadism".

"However, this is now speculative".

"Our immediate concern is for the fertility of men who use these drugs for a long time".

Now, before you panic, there's no suggestion yet that occasionally relying on an ibuprofen will make your balls shrivel up and die.

While it is certain that the hormonal effects in the study participants who used ibuprofen for only a short time are reversible, as CBS reported, it's unknown whether this is also true after long-term ibuprofen use, study co-author Bernard Jegou, director of the Institute of Research in Environmental and Occupational Health in France, told CNN. In the wake of this research, they focused their investigation on ibuprofen, which seemed to have the strongest effects.

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